Financial and materials companies led U.S. stocks sharply lower in morning trading Monday following another slide in European markets as investors grappled with the fallout of Britain's vote to leave the European Union.
The British pound, which last week plunged to its lowest level since 1985, continued to fall as traders expected the British economy would take a hit.
The Dow Jones industrial average lost 295 points, or 1.7 percent, to 17,105 as of 11:13 a.m. Eastern Time. The Standard & Poor's 500 index slid 40 points, or 2 percent, to 1,996. The Nasdaq composite fell 119 points, or 2.5 percent, to 4,588.
The latest decline followed the market's plunge on Friday, when the Dow and S&P 500 clocked their biggest losses since August, and the Nasdaq notched its worst day since August 2011. Despite the losses, the market is still well above the lows it reached in early February, when the S&P 500 closed as low as 1,829.
Banks and other financial companies slumped as investors speculated that the global economic uncertainty caused by Britain's decision to leave the EU will prompt the Federal Reserve to hold off on raising its benchmark interest rate. Banks benefit from higher interest rates, which translate into more revenue from loans and credit cards.
"A lot of the expectations about what these financial stocks would be worth have changed," said JJ Kinahan, chief strategist at TD Ameritrade. "This sort of takes Fed rate raises off the table for a while, maybe through the end of 2016."
Charles Schwab fell $1.97, or 7.5 percent, to $23.65, while JPMorgan Chase slid $2.39, or 4 percent, to $57.21. Wells Fargo was down $1, or 2.2 percent, at $44.71.
Materials and technology stocks also fell sharply. Energy companies declined as the price of U.S. crude oil headed lower.
European stock markets added to their painful losses from Friday, when concern over the vote outcome wiped out $2.1 trillion of stock value from Hong Kong to London to New York.
Britain's FTSE 100 was down 2.5 percent, while Germany's DAX was down 3.3 percent. France's CAC 40 was down 3.4 percent.
Traders were watching for more aftershocks as EU leaders press London to start the complex process of leaving the 28-nation trading bloc. Prime Minister David Cameron wants to wait several months.
"Markets will be nervous given that the EU and U.K. have some mismatch in terms of timing of exit procedures and negotiations," said Mizuho Bank analysts in a report.
"The EU's legitimacy may be tested by separatist parties," it said. "Spanish elections more immediately and then French elections in 2017 add to the complexity of political dynamics involved in negotiations. Brewing uncertainty suggests that the stage is set for potentially stormy global markets."
In the first direct reflection of business sentiment in Britain, a leading business group said Monday that 20 percent of its members plan to move some of their operations outside of the U.K. in light of the country's decision to leave the EU. The Institute of Directors said that a survey of its 1,000 members showed that three out of four believe that Britain's exit from the EU, or Brexit, will be bad for business.
Earlier, some Asian markets had bounced back somewhat following reports that Japanese Prime Minister Shintaro Abe instructed financial officials to take steps to stabilize financial and currency markets. Tokyo's Nikkei 225 rose 2.4 percent, making up some of the ground it lost on Friday, when it closed nearly 8 percent lower.
The Shanghai Composite Index gained 1.2 percent, while Hong Kong's Hang Seng shed 0.2 percent. Seoul's Kospi rose 0.1 percent.
Bond prices rose. The yield on the 10-year Treasury note fell to 1.47 percent from 1.56 late Friday.
In currency markets, the British pound slid to $1.3182 from $1.3638 late Friday, despite the British Treasury's reassurances that the economy was strong enough to withstand the uncertainty. The euro weakened to $1.0989 from $1.1121, while the Japanese yen fell to 101.62 from 102.24.
In energy futures trading, benchmark U.S. crude was down $1.22, or 2.6 percent, at $46.42 a barrel in New York. Brent crude, used to price international oils, was down $1.09, or 2.3 percent, at $47.32 in London.
AP Business Writers Danica Kirka in London and Joe McDonald in Beijing contributed to this report.