J. Scott Applewhite, File, Associated Press
In this March 4, 2015 file photo, Senate Minority Leader Harry Reid of Nev. gestures during an interview with The Associated Press in his office on Capitol Hill in Washington. Reid is announcing he will not seek re-election to another term.

U.S. Sen. Harry Reid said Friday that he won't seek re-election in 2016. Officials react to the Democratic majority leader's announcement he will retire after five terms:

"Harry Reid is a fighter. In his five terms as a U.S. senator, Harry has fought for good jobs, a safer environment for our kids, and affordable health care for all. As the leader of the Senate Democrats during my time in office, Harry has become not only an ally, but a friend. I know the Senate will not be the same without him." — President Barack Obama

"Sen. Reid has been an influential voice in Congress on behalf of Nevada's interests, particularly on issues such as Yucca Mountain and renewable energy development. His service to Nevada as a state legislator, lieutenant governor, congressman and senator spans almost half a century and his legacy will last for generations." — Nevada Gov. Brian Sandoval

"Throughout his time on the Hill, there was never any doubt his actions always put the interests of the Silver State first. Harry's coming home to Nevada. I have no doubt his family is looking forward to catching up on lost time, especially the grandchildren. I look forward to working with him for the next 22 months." — U.S. Sen. Dean Heller, R-Nev.

"Harry Reid changed the course of history. His leadership on issues of health care and environmental protection has left legislative landmarks unlikely ever to be matched. The desert is blooming with solar plants, some 73,000 previously uninsured Nevadans now have coverage, and Tule Springs is protected, all thanks to Sen. Reid." — U.S. Rep. Dina Titus, D-Nev.

"Congressman Heck wishes Sen. Reid well in his retirement and will remain focused on serving Nevadans in the House." — Greg Lemon, spokesman for U.S. Rep. Joe Heck, R-Nev.

"On the verge of losing his own election and after losing the majority, Sen. Harry Reid has decided to hang up his rusty spurs. Not only does Reid instantly become irrelevant and a lame duck, his retirement signals that there is no hope for the Democrats to regain control of the Senate." — Ward Baker, National Republican Senatorial Committee executive director

"As the leader of Senate Democrats for the past decade, he shepherded some of our greatest legislative achievements on behalf of the American people, including the Affordable Care Act and Wall Street reform." — U.S. Rep. Debbie Wasserman, D-Fla., Democratic National Committee chairwoman

"No one fights the good fight harder than Harry Reid. From Lake Tahoe to Great Basin National Park to Red Rock Canyon, Senator Reid has protected Nevada's unique treasures in every corner of the state for future generations." — Gene Karpinski, president of the League of Conservation Voters

"With the Democratic Party already in disarray, a national committee struggling to raise money, and a scandal-plagued presidential front-runner, it's no surprise Harry Reid realized he was about to suffer a humiliating defeat and decided to step aside." — Republican National Committee press secretary Allison Moore

"Sen. Reid has been a tireless supporter of gaming who solidified Nevada and the industry's significance across the country. From his earliest days as chairman of the Nevada Gaming Commission to his years in the United States Senate, Senator Reid has been a visionary for what could be possible." — Geoff Freeman, American Gaming Association president and chief executive officer

"On behalf of the Nevada Senate Democrats, I want to thank him for his advocacy, his mentorship, and his dedication to the people of our state." — Nevada Senate Democratic Leader Aaron Ford, D-Las Vegas