OAKLAND, Calif. — All the good work the Oakland Raiders did on defense in the first 26 minutes was erased in an instant when C.J. Anderson broke three tackles and weaved through the entire unit on the way to a long touchdown.
Peyton Manning followed that score with another four touchdown passes on the next four drives and the Denver Broncos handed the Raiders their 15th straight loss, 41-17 on Sunday.
"There seems to be a play every game that happens to us and then everything kind of snowballs from there," safety Charles Woodson said. "There were a couple missed tackles, mine included, which I feel like, man, 'I'm part of the play that really turned the game around.' That's one I'll be thinking about all night."
Manning had looked rather ordinary before that touchdown, throwing two interceptions and failing to lead Denver (7-2) into the end zone.
But he was his usual self after it, throwing two passes to Julius Thomas and two more to Emmanuel Sanders as the Broncos rebounded from last week's loss at New England by beating up on the Raiders (0-9).
Manning threw for 340 yards and extended his record with at least two touchdown passes to 15 straight games.
"Obviously, he adjusted," Raiders defensive lineman Justin Tuck said. "That's why, if he is not the best quarterback to ever play this game, he's definitely one of the best. He adjusted and we weren't able to adjust well enough to keep up."
Anderson, who grew up in nearby Vallejo and attended college at California, finished with 90 yards rushing and 73 receiving. Demaryius Thomas had 11 catches for 108 yards.
There was almost nothing positive from the Raiders in their first blowout loss since interim coach Tony Sparano replaced the fired Dennis Allen after four games.
Derek Carr threw for 192 yards on 47 attempts, most of the production coming on a meaningless touchdown drive in the closing minutes. He also had two interceptions. The running game was limited to 30 yards on 15 carries and the defense was completely overmatched after a spirited start.
"They're looking for the gold at the end of the rainbow and it hasn't been there," Sparano said. "We have to stay the course and believe in the things that we're doing and we're getting better as a football team. I know this is not an indicator of that."
The game — and season — could be summed up in one play for Oakland early in the third quarter. Carr was under pressure when he dumped off a pass to offensive lineman Khalif Barnes. Barnes looked shocked when he caught the ball, but ran with it despite an ineligible receiver. Malik Jackson knocked the ball loose and Chris Harris Jr. recovered at the 18.
Carr said he expected running back Darren McFadden to be in that spot so he threw the ball without looking.
"It's just one of those things, you know where your guy's at, you react," Carr said. "Everything is happening so fast. It's just one of those things. Obviously, where we're at right now, it just looks ugly, but it's just one of those things that happens."
That set up a 10-yard touchdown pass to Julius Thomas that put the Broncos up 28-10 and in control.
Manning struggled early, throwing an interception on the second play from scrimmage to DJ Hayden. That set up a 41-yard field goal by Sebastian Janikowski that gave the Raiders their first lead against the Broncos since Tim Tebow was the Denver quarterback in 2011.
The Broncos then got field goals on a pair of drives inside the Oakland 20 as Manning struggled to get into rhythm. The problems for Manning got worse when Tuck made an athletic interception, jumping to tip a pass and then catching it himself to give Oakland the ball at the 12.
Carr capitalized with a 5-yard pass to Brice Butler that put the Raiders up 10-6.
The game quickly changed after Carr was intercepted by Bradley Roby on a poor pass over the middle.
On third-and-8, Manning threw a short pass to Anderson, who immediately broke a tackle from Miles Burris. He then ran attempts by Khalil Mack and Woodson on his way to the end zone.
"Just a truly incredible effort play on his part to take a potentially catch for a loss and turn it into a 50-something-yard touchdown," Manning said. "That really gave us a spark."
After a three-and-out by Oakland, Manning added a 32-yard touchdown pass to Sanders that put Denver up 20-10 at the half.
NOTES: The Raiders failed to gain a first down rushing for the first time since 2006. ... Hayden (groin) and RT Menelik Watson (head) left the game with injuries.