J. Scott Applewhite, Associated Press
Senate Majority Leader Harry Reid, D-Nev., speaks to reporters following a budget vote late in the day, Wednesday, May 25, 2011, at the Capitol in Washington.

WASHINGTON — The Senate has voted to reject the latest House Republican effort to negotiate on the budget amid the government shutdown.

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The party-line vote was 54-46 on Tuesday. The Senate turned aside a House request to name negotiators to a conference to resolve differences.

Majority Leader Harry Reid said he wouldn't negotiate as long as Republicans were holding up a straightforward spending bill to keep the government operating.

The vote marked the fourth time during this fight that the Democratic-controlled Senate has rejected House Republican efforts. The political stalemate that has triggered the first government shutdown in 17 years.