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Associated Press
Egyptian protesters throw stones while security police open water canons on them from inside the grounds of the presidential palace during a demonstration in Cairo, Egypt, Friday, Feb. 8, 2013. Egypt has witnessed a fresh cycle of violence over the past two weeks since the second anniversary of the 2011 uprising that deposed longtime autocrat Hosni Mubarak, with clashes across the country having left scores dead and hundreds injured. (AP Photo/Khalil Hamra)

CAIRO — Egyptian security forces backed by water cannons fired tear gas at rock-throwing protesters outside the presidential palace in Cairo on Friday while demonstrators clashed with riot police in cities across the country in marches against Islamist President Mohammed Morsi.

The protests are part of a wave of opposition-led demonstrations over the past two weeks that have frequently devolved into street clashes. The violence has left more than 70 people dead and hundreds wounded, and plunged the country into a fresh cycle of bloodshed and political turmoil.

Egypt's opposition is demanding Morsi form a new coalition government, open an investigation into the killings of protesters over the past months and give guarantees that upcoming parliamentary elections will be fair and free. They also want him to form a commission to amend the country's newly adopted constitution, which was drafted by an Islamist-led panel and approved last December in a contentious referendum.

Some of the protesters go even further, demanding Morsi be removed from office. They also accuse the Muslim Brotherhood, the fundamentalist group from which Morsi hails, of monopolizing power and failing to deal with the country's mounting woes.

Thousands took their demands to the streets in cities across the country on Friday, carrying Egyptian flags and pictures of slain protesters and chanting "down with the rule of the Guide," referring to Brotherhood Supreme Guide Mohammed Badie, who critics allege is calling the shots for Morsi from behind the scenes.

At the presidential palace in Cairo, the scene of repeated violent clashes since late last year, protesters tried to remove the barbed wire at the front gate of the palace and fired flares at its perimeters. Riot police swiftly responded with water cannons and tear gas while protesters hurled stones.

Violence also broke out in Kafr el-Sheik, some 110 miles north of Cairo, where riot police clashed with protesters in front of the office of governor Saad el-Husseini, who is a member of the Muslim Brotherhood.

In the Mediterranean port city of Alexandria, protesters tore down a Brotherhood sign and burned it in front of the group's office while security forces used tear gas to disperse demonstrators in front of the governor's office.

Morsi and his allies accuse the opposition of trying to incite street violence to seize power after failing at the ballot box.

In a statement on Friday, Murad Ali, a spokesman for the Freedom and Justice party — the Muslim Brotherhood's political arm — warned the opposition that it would be responsible for any acts of violence that occur during protests. He also called them "losers."

The clashes over the past two weeks have fueled a sense that Egypt is coming unglued, while also raising concerns that the country could be hit by more — and greater — political violence.

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Those worries sharpened after the assassination of a prominent anti-Islamist opposition leader in Tunisia on Wednesday, a killing that touched off a new wave of unrest there.

Tunisia was the birthplace of the region's so-called Arab Spring uprisings in 2011 that brought an end to the rule of several autocrats including Egypt's own Hosni Mubarak, clearing the way for Morsi's election last summer. Egyptians have warily watched the events unfolding in Tunis, which many here look to as a bellwether for their own country.