LOS ANGELES (AP) — Southern California turned the most anticipated September game in years into a mismatch.

Mark Sanchez threw four touchdown passes, Joe McKnight rushed for 105 yards on 12 carries, and the top-ranked Trojans crushed No. 5 Ohio State 35-3 Saturday night in a matchup of two of college football's most successful programs.

Ohio State played without star tailback Chris "Beanie" Wells, sidelined with an injured right foot. But moving the ball wasn't the Buckeyes' biggest problem before the Trojans made it a rout. Instead, they were done in by a handful of crucial mistakes.

A holding penalty nullified a touchdown in the second quarter, and an errant throw by Todd Boeckman was intercepted and returned for a touchdown by Rey Maualuga.