Ryan Denney

CAN'T MISS: Tony Romo. He'll score big in Cleveland.

SLEEPER: Chris Johnson. Should spark Titans offense.

NOT THIS WEEK: Peyton Manning. Get ready for hand-offs.

FREE AGENT PICK UP: Jabar Gaffney. He'll produce for Pats.

Bigger role: Former Ute superstar Eric Weddle begins his first full season as a starter for the Chargers today. He showed enough as a rookie to secure a starting spot at safety.

Bears (0-0) at

Colts (0-0)

NBC, 6:15 p.m.

Indy's new stadium gets its regular-season christening, but will Colts QB Peyton Manning be at full speed? He didn't play in an exhibition game following knee surgery.

Prediction: Colts 27, Bears 16

Seahawks (0-0) at

Bills (0-0)

Fox, 11 a.m.

Buffalo should have a solid defense, and the offense is led by QB Trent Edwards, who emerged last season, as well as second-year RB Marshawn Lynch. Seahawks QB Matt Hasselbeck has a bad back.

Prediction: Bills 20, 'Hawks 17

Jets (0-0) at

Dolphins (0-0)

CBS, 11 a.m.

Brett Favre makes his much-hyped debut and faces a team that was 1-15 last year and has undergone a major overhaul. Ex-Jet Chad Pennington leads Miami.

Prediction: Jets 24, 'Fins 17

Vikings (0-0) at

Packers (0-0)

ESPN, Monday, 5 p.m.

The opener of the Monday doubleheader is the coming out party for Green Bay QB Aaron Rodgers, who gets his first NFL start after three seasons as Favre's backup. The Vikes unleash RB Adrian Peterson.

Prediction: Vikings 20, Pack 17

Broncos (0-0) at

Raiders (0-0)

ESPN, Monday, 8:15 p.m.

QB JaMarcus Russell gets his second NFL start as another new Raiders era begins, with ballyhooed rookie RB Darren McFadden. Denver QB Jay Cutler begins his second season as the full-time starter.

Prediction: Raiders, 17-16