Donovan McNabb, Eagles, threw for 361 yards and three touchdowns in Philadelphia's 38-3 win over St. Louis.
Drew Brees, Saints, had 343 yards and three touchdowns in New Orleans' 24-20 win over Tampa Bay.
Tony Romo, Cowboys, was 24-of-32 for 320 yards and a TD in Dallas' 28-10 win over Cleveland.
Brett Favre, Jets, was 15-for-22 for 194 yards with two TDS in New York's 20-14 win over Miami.
Jake Delhomme, Panthers, was 23-of-41 for 247 yards and threw the winning TD as time expired in Carolina's 26-24 win over San Diego.
Ben Roethlisberger, Steelers, was 13-for-14 with two TDs in Pittsburgh's 38-17 win over Houston.
Matt Ryan, Falcons, threw for a touchdown on his very first NFL pass in Atlanta's 34-21 win over Detroit.
Matt Cassel, Patriots, was 13-of-18 for 152 yards and a TD in relief of Tom Brady in New England's 17-10 win over Kansas City.
Michael Turner, Falcons, set a team record with 220 yards in Atlanta's 34-21 win over Detroit.
Willie Parker, Steelers, ran for 138 yards and three touchdowns in Pittsburgh's 38-17 win over Houston.
Rookie Chris Johnson, Titans, ran 15 times for 93 yards and had three receptions for 34 yards and a TD in Tennessee's 17-10 win over Jacksonville.
Brian Westbrook, Eagles, ran for 91 yards and scored two TDs in Philadelphia's 38-3 win over St. Louis.
Thomas Jones, Jets, had 101 yards and a touchdown in New York's 20-14 win over Miami.