Tom Strickland, Associated Press
Buffalo Bills' running back Dwayne Wright is wrapped up by the Colts' defenders Brannon Condren, left, and Ed Johnson during the Bills 20-7 win over the Colts.

INDIANAPOLIS — The Buffalo Bills ruined Indianapolis' grand opening celebration Sunday night.

Xavier Omon ran for one touchdown, Terrence McGee returned a fumble for another score and Rian Lindell kicked two field goals, leading the Bills to a 20-7 victory over the mistake-prone Colts in the new Lucas Oil Stadium debut.

Little went right for the Colts after they opened the new roof and the sliding window in the back of the north end zone less than 30 minutes before kickoff.

J.P. Losman, who replaced injured Trent Edwards at quarterback, helped the Bills play keepaway in the first half, running more than twice as many plays as the Colts.

Omon scored on a 1-yard run with 5 minutes left in the half to make it 10-0, and McGee ended Indy's only decent drive of the half by scooping up Joseph Addai's and sprinting 68 yards for a score to make it 17-0 with 1:43 to go.

The Colts only score came on a 94-yard touchdown pass from Quinn Gray to Devin Aromashodu late in the third quarter.

Indy played without either of its top quarterbacks, Peyton Manning or Jim Sorgi. Sorgi was a late scratch because of a gimpy knee. Manning hasn't played since having knee surgery in mid-July, and Gray threw four interceptions.

Buffalo lost left tackle Langston Walker early in the second quarter with an injured left forearm.