Al Behrman, Associated Press
Los Angeles Dodgers starter Derek Lowe pitches against the Cincinnati Reds in the first inning of his first road win since August.

CINCINNATI — So many times on the road, Derek Lowe deserved to win. In each of his last 11 tries, he came up short for one reason or another — no run support, no help from the bullpen, no breaks.

On a night when he felt awful, everything finally went his way.

Lowe earned his first road win since last August by pitching into the sixth inning, and the Los Angeles Dodgers extended their season-long domination of the Cincinnati Reds with a 6-1 victory on Wednesday night.

James Loney had a solo homer and a run-scoring double off Bronson Arroyo (4-6), sending the Dodgers to their sixth victory in seven games against the Reds this season. Juan Pierre broke the game open with a two-run triple in the seventh.

"I don't know what it is about the Dodgers," Reds manager Dusty Baker said. "They beat us pretty good."

Lowe (5-6) hadn't beaten anybody on the road since Aug. 22 in Philadelphia. He went 0-6 in his next 11 starts away from Dodger Stadium.

It wasn't entirely his fault. Lowe often has pitched well enough, but the offense has let him down. This time, he knew he'd need a little help and a little luck.

Hiroki Kuroda was scheduled to start on Wednesday, but told the team a day earlier that he had a sore pitching shoulder. By that point, Lowe had already done a strenuous off-day workout. He was moved up a day and took Kuroda's place, but knew not to expect much.

Lowe gave up three hits, including Edwin Encarnacion's solo homer, and matched his season high with six strikeouts. Manager Joe Torre took him out after his 85th pitch in the sixth inning with Los Angeles ahead 4-1.

"I may be prouder of this game than any," Lowe said. "It was an absolute struggle from the first pitch. You go out there and go as far as you can."

He finally broke through on the road against Arroyo, one of his teammates on Boston's 2004 World Series championship team.

"He pitched a great game," Arroyo said. "Once we got behind, you knew we weren't going to catch up."

Interleague

RED SOX 7, PHILLIES 4: At Philadelphia, J.D. Drew tied a career-high with four hits and fell a triple short of the cycle for Boston. Drew hit a three-run homer in the first inning, doubled in the third, had an RBI single in the fourth and singled in the sixth before tapping out in the eighth. He finished 4-for-5 with four RBIs.

TIGERS 7, GIANTS 2: At San Francisco, Placido Polanco had four hits, drove in two runs and scored three as Detroit knocked struggling San Francisco starter Barry Zito out after two innings. Armando Galarraga (7-2) didn't allow an earned run in six innings and struck out five to win his third straight start and fourth consecutive decision. Marcus Thames had his stretch of consecutive games with a home run end at five, which tied a team record. Still, his last eight hits have been homers.

ORIOLES 2, ASTROS 1 (10): At Baltimore, Kevin Millar singled in the game-winning run in the 10th inning, and Baltimore handed Houston its seventh straight loss. It was the fourth straight one-run game for the Orioles, three of them victories. Baltimore is 17-10 in one-run games compared to 13-31 last year.

RAYS 5, CUBS 4: At St. Petersburg, Fla., Andy Sonnanstine allowed three runs in five-plus innings for Tampa Bay. The Rays clinch their ninth consecutive series at home.

WHITE SOX 8, PIRATES 2: At Chicago, Toby Hall hit his first home run in two years and Carlos Quentin slugged his 17th this season for Chicago. Mark Buehrle (4-6) gave up two runs and four hits with two walks in eight innings. He struck out three and threw only 96 pitches. He lost a no-hit bid in the sixth when Jose Bautista homered on the first pitch.

ROYALS 3, CARDINALS 2: At St. Louis, David DeJesus and Alex Gordon hit solo home runs in the eighth inning to rally Brian Bannister and Kansas City. Last in the AL Central, the Royals improved to 6-2 in interleague play and will try for a three-game sweep of their cross-state rivals Thursday. Kansas City had been 0-37 this season when trailing after seven innings.

TWINS 11, NATIONALS 2: At Minneapolis, Kevin Slowey won his second straight start since his worst outing of the year and Justin Morneau had three RBIs for Minnesota. Carlos Gomez of the Twins bunted for two of his three singles, scored two runs and drove in an insurance run in the seventh.

BRAVES 5, RANGERS 2: At Arlington, Texas, Omar Infante hit a tiebreaking single and Atlanta scored three times in the ninth inning. Jeff Francoeur led off the inning with a grounder that Rangers closer C.J. Wilson threw wildly to first for a two-base error. One out later, Infante singled to right to drive in Francoeur, and Gregor Blanco followed with a run-scoring triple to right-center. Kelly Johnson added his second RBI of the game with a run-scoring groundout to make it 5-2.

BREWERS 5, BLUE JAYS 4: At Milwaukee, Mike Cameron and Russell Branyan homered for Milwaukee, which won its third straight. Relievers Carlos Villanueva, Brian Shouse, Guillermo Mota and Salomon Torres, who picked up his ninth save by getting four outs, combined to give up two runs and six hits after starter Ben Sheets (8-1) left with a 4-2 lead after giving up four hits in six innings.

YANKEES 8, PADRES 5: At New York, Alex Rodriguez homered for the fourth straight game and New York set a season high with its sixth consecutive victory. Darrell Rasner (4-4) walked five in five innings, but yielded only two runs and three hits to snap his four-start losing streak. New York beat NL Cy Young Award winner Jake Peavy (5-4), who gave up four runs — three earned — and six hits in four innings in his second start since coming off the disabled list.

ROCKIES 4, INDIANS 2: At Denver, Jeff Baker homered and scored three runs and Jeff Francis allowed one run over six innings for Colorado. Omar Quintanilla went 2-for-3 and had two RBIs for the Rockies, who have won four of five.

DIAMONDBACKS 11, ATHLETICS 1: At Phoenix, Dan Haren allowed one run and drove in three for Arizona against his old team. Haren (7-4) limited the A's to four hits in seven innings, walking one and striking out eight. He hit a three-run double as the Diamondbacks paid back the A's for a 15-1 drubbing in the series opener.

MARLINS 8, MARINERS 3: At Seattle, Dan Uggla and Mike Jacobs hit long two-run homers for Florida and the top home run hitting team in the majors added to its league-leading total.

METS 5, L.A. ANGELS 4 (10): At Anaheim, Calif., Jerry Manuel got his first win managing the Mets when New York rallied in the ninth inning and Damion Easley homered in the 10th to beat Los Angeles. Manuel, who replaced the fired Willie Randolph, lost his debut with the Mets 6-1 Tuesday night.