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Sue Ogrocki, Associated Press
A dog trapped in tornado rubble in Picher, Okla., tries to climb out of the debris on Monday. The dog was freed soon after.

PICHER, Okla. — Ralph Morris got out of his bedroom — practically the only part of his house the tornado left standing — and saw a 13-year-old girl getting up in the backyard. She was marked by cuts and bruises, and all alone.

"We got her to the bathroom and got her sat down and got her in a blanket. She was hurt real bad," he said.

Moments earlier the girl had been in a car with her family. Picher Fire Chief Jeff Reeves said they appeared to have been on their way to help a relative in another part of town.

"I saw the way the debris was flying so I knew if there was any survivors, they were in that direction," Morris said, pointing east toward the lagoon.

"I went over there searching, hopefully to find someone and I found her uncle in the tree. He was gone. I found another body in the lagoon," where the car and a third body were found.

Of the 22 people killed by the tornado that smashed parts of Oklahoma and Missouri on Saturday, more than one-third of them died in cars, troubling experts who say vehicles are among the worst places to be during a twister.

"It's like taking a handful of Matchbox cars and rolling them across the kitchen floor," said Sgt. Dan Bracker of the Missouri State Highway Patrol, surveying the damage in and around Seneca, near the Oklahoma line, the hardest hit area. "This is devastating."

Among those killed were four family members — Rick Rountree, his wife, his 13-year-old son, and his mother-in-law — who were in a van on the way to a friend's wedding when the twister, packing winds of 170 mph, struck the Seneca, Mo., area on Saturday night.

"They were on the road when the warnings came," said Rountree's brother-in-law, Larry Bilke.

About 100 people have died in U.S. twisters so far this year, the worst toll in a decade, according to the National Weather Service, and the danger has not passed yet. Tornado season typically peaks in the spring and early summer, then again in the late fall.

This could also prove to be the busiest tornado season on record in the United States, though the final figure on the number of twisters is not yet in.

All together, at least 25 people died in Missouri, Oklahoma, Georgia and Alabama after the severe storms erupted Saturday over the Southern Plains and swept east.

The death toll rose Monday when Tyler Casey, a 21-year-old firefighter in Seneca, died at a hospital. Officials said he got caught in the tornado while trying to warn people to seek shelter.

According to data from the National Weather Service's Storm Prediction Center, 49 of the 705 deaths — or about 7 percent — attributed to tornadoes from 1997 to 2007 were people who were in vehicles when the storm struck.

"They can cover more ground than you can in your car, so unless you know you are moving away from the tornado the best thing you can do is find a strong structure," said weather service meteorologist Andy Foster.

The twister that struck Seneca and surrounding Newton County was moving at 50 mph to 60 mph, Foster said. One car was found a half-mile from the tornado track.

Authorities were still piecing together how some of the other victims died over the weekend. But the Missouri Highway Patrol said one person was killed when her vehicle was blown off the same road where the Rountree family died.

Another woman was critically injured after she took shelter in a broken-down car outside Susan Roberts' home in Seneca, authorities said. "That is what is tearing me up," Roberts said, adding she had warned the woman about the approaching tornado.

Val Castor, one of the many spotters who bring dramatic video of tornadoes to local TV stations in Oklahoma, said the number of people on the road during tornadoes seems to have increased every year since 1996, when the movie "Twister," which depicts meteorologists chasing tornadoes, came out.

He said driving during severe weather is extremely dangerous for the inexperienced because they don't know where a tornado will form or what direction it will go. Heavy traffic or a broken-down vehicle can prevent people from escaping the funnel cloud.

"Vehicles of any size really don't fare that well in a tornado. Vehicles can be thrown and tossed by the wind," said Rick Smith, warning coordination meteorologist with the weather service in Oklahoma.

As with mobile homes, the problem with cars is that they are not anchored to the ground, and the wind can easily get underneath them. Smith said winds of less than 100 mph can flip a car.

"That is probably the worst place that you can be when a tornado, or even some of the severe storms that we see in Oklahoma, happen," he said.

Smith said people should avoid driving when severe storms are forecast and seek shelter in a truck stop, restaurant or other permanent structure if caught on the road during a twister. As a last resort, Smith said, motorists should get out and find a low-lying area, such as a culvert or a ditch, where they can duck and cover.

Weather experts say overpasses should be avoided because the wind can become more powerful as it squeezes through.

"Paying attention to the weather and not being caught in that situation is really your best bet," Smith said.

The warnings against staying in cars were prompted by a tornado that struck Wichita Falls, Texas, in 1979. Of the 42 deaths, 25 were vehicle-related.

The U.S. death toll from tornadoes this year is the highest since 130 people were killed in 1998, according to the weather service. The highest number of tornado-related deaths came in 1953, when 519 people died.

To date this year, 858 tornadoes have been reported in the U.S., although that number probably includes numerous duplicate sightings of the same twister.

Harold Brooks of the National Severe Storms Laboratory said the highest number of tornadoes ever recorded through May 11 of any year was in 1999, when 676 tornadoes were counted. Brooks said he expects the number of confirmed tornadoes through mid-May of this year to end up in the 650-to-700 range.

Altogether, 16 people died in Missouri from the same storm that devastated Picher, where six were killed. Two more people were killed in Georgia, where forecasters said at least six tornadoes touched down. One of those twisters struck McIntosh County's emergency management center, destroying the fire trucks and ambulances inside. Another man was killed in Alabama when his truck was hit by a tree limb as he was surveying storm damage.

The Environmental Protection Agency said it would check for high lead levels in Picher after the tornado blew through the heavily polluted former mining town where lead-filled waste is piled into giant mounds.

Miles Tolbert, Oklahoma secretary of the environment, said he did not believe there was any immediate hazard to the 800 residents. But he said more testing was needed.