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Michael Perez, Associated Press
Miami Heats' LeBron James (6) is fouled by Philadelphia 76ers' Evan Turner (12) in the first half of an NBA basketball game on Friday, Feb. 3, 2012, in Philadelphia.

PHILADELPHIA — Dwyane Wade scored 26 points, and LeBron James had 19 points and 12 rebounds to lift the Miami Heat to a 99-79 win over the Philadelphia 76ers on Friday night.

Mario Chalmers scored 13 points and Chris Bosh had 12 to help the Heat go on a dominant late run that put away the pesky Sixers.

The Heat used a 15-0 spurt in the fourth quarter to turn a tight one for 36 minutes into a comfortable victory and hand the Sixers just their third home loss of the season.

Thaddeus Young scored 16 points for the Sixers, who snapped a four-game winning streak.

Wade used a pair of ferocious dunks during the game-changing run that pushed the Sixers' first sellout crowd of the season toward the exits.

The Sixers opened the week with wins against Orlando and Chicago. The Heat squashed the home-week sweep.