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Muzaffar Salman, Associated Press
A pro-Syrian regime protester kisses a portrait of Syrian President Bashar Assad during a demonstration in support of their President, in Damascus, Syria, on Wednesday Jan. 4, 2012. Activists accused President Bashar Assad's regime on Wednesday of misleading Arab League observers by taking them only to areas loyal to the government and changing street signs to confuse them.

DAMASCUS — A Syrian official says an explosion has targeted a police bus in central Damascus, causing deaths.

State TV also reported a blast in the Damascus central neighborhood of Midan, which killed and wounded a number of people.

Friday's explosion comes two weeks after two blasts in Damascus targeting security buildings killed 44 people.

The official, speaking on condition of anonymity because he was not allowed to talk publicly to the media, gave no further details.