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Ed Reinke, Associated Press
Louisville quarterback Will Stein readies a pass during the first half of their NCAA college football game against Florida International, Friday, Sept. 9, 2011, in Louisville, Ky.

LOUISVILLE, Ky. — Winston Fraser returned an interception 71 yards, and T.Y. Hilton scored touchdowns on his first two catches as FIU upset Louisville 24-17 on Friday night, the Panthers' first win in six tries against the Big East Conference.

The Panthers (2-0) never trailed as Fraser stepped in front of a pass by Will Stein and ran up the left sideline for the TD midway through the first quarter. Hilton had a school-record 201 yards receiving, and the Panthers had five sacks and two turnovers in the big win for the defending Sun Belt Conference champs.

Louisville (1-1) had never played FIU before, and the Cardinals had been 25-8 against nonconference opponents since joining the Big East in 2005.