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Elise Amendola, Associated Press
Chicago White Sox's Alexei Ramirez fouls a ball off against the Boston Red Sox in the sixth inning of a baseball game at Fenway Park in Boston Tuesday, May 31, 2011. Ramirez tied his career high with four hits in the White Sox 10-7 victory over the Red Sox.

BOSTON — Paul Konerko hit a go-ahead single in the seventh inning and a two-run homer in the ninth to lead the Chicago White Sox to a 7-4 win over the Boston Red Sox on Wednesday and a sweep of their three-game series.

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Boston, which had just two hits in the last seven innings, lost its fourth straight game for the first time since a six-game, season-opening slide.

Gavin Floyd (6-5) allowed four runs in 6 2-3 innings and improved to 2-5 in day games. Sergio Santos pitched the ninth for his ninth save in 10 opportunities.

Matt Albers (1-3) replaced Tim Wakefield to start the seventh and retired just one of the four batters he faced, allowing singles to the other three, including one to Konerko.

Konerko's homer was the 377th of his career, tying Norm Cash and Jeff Kent for 64th place all-time. He has 12 this season and two in his last two games.