OTTAWA Sidney Crosby, Jordan Staal and Marian Hossa scored in the third period to lift Pittsburgh over Ottawa, taking a 3-0 lead in their first-round series.
Maxime Talbot scored in the second period and Hossa also had two assists to push his former team to the brink of elimination one year after beating Pittsburgh in five games on its way to the Stanley Cup finals.
Game 4 is Wednesday at Scotiabank Place.
Crosby got the tiebreaking goal 12 seconds into the third, stunning the Senators' crowd with his first goal of the playoffs after busting in on a 2-on-1 break and snapping a shot that beat Martin Gerber stick side.
Staal made it 3-1 just 1:18 later, crashing the net and redirecting Kristopher Letang pass behind a helpless Gerber. Hossa capped the comeback with a power-play goal at 8:55.
Ottawa couldn't capitalize on the return of injured captain Daniel Alfredsson, a surprise addition to the Senators' lineup. Alfredsson, who hadn't played since he was injured on April 3, was given a standing ovation when he took his first shift 42 seconds into the first period.
PREDATORS 5, RED WINGS 3: At Nashville, Jason Arnott scored with 3:58 left in the final period, the second Nashville goal in 9 seconds, and the Predators rallied to beat the Detroit Red Wings 5-3to get back into the first-round series.
Ryan Suter tied the game just 9 seconds earlier, putting a slap shot from the left side past Dominik Hasek, who had dominated the Predators for most of the game and the series. Martin Erat scored an empty-netter with 41 seconds left to seal the come-from-behind win.
Nashville, which trails 2-1, will look to tie the series in Game 4 on Wednesday night, and the series will then shift back to Detroit on Friday.WILD 3, AVALANCHE 2: At Denver, Pierre-Marc Bouchard scored with 11:58 left in overtime to lift the Wild past the Avalanche to give Minnesota a 2-1 advantage over Colorado in their first-round playoff series.
Stanley Cup playoffs
Pittsburgh 4, Ottawa 1, Penguins lead series 3-0
Nashville 5, Detroit 3, Wings lead series 2-1
Minnesota 3 at Colorado 2 (OT), Wild lead series 2-1
Montreal at Boston, 5 p.m.
Washington at Philadelphia, 5 p.m.
Anaheim at Dallas, 6:30 p.m.
San Jose at Calgary, 8 p.m.
Minnesota at Colorado, 8 p.m.