LAS VEGAS — Health officials here sensed something was wrong.

It was January, and two acute cases of hepatitis C had been reported to authorities — the number Clark County averages in a year. The patients, they soon discovered, had one thing in common: Both had undergone procedures at the same medical clinic.

When investigators arrived at the Endoscopy Center of Southern Nevada, they witnessed staffers reusing medicine vials and syringes during anesthesia, a practice that can transmit blood-borne diseases.

The safety lapses — purportedly in place to cut costs — dated to at least 2004.

As a result, 40,000 people have been told to seek testing for hepatitis and HIV, the virus that causes AIDS, in what federal officials are calling the largest notification of its kind in history.

The public-health scare has cut across racial and socioeconomic lines, bringing Southern Nevada residents together through a shared sense of panic and mistrust.

"These people have psychically cracked," said Dr. Michael Karagiozis, an HIV specialist at the Community Counseling Center in Las Vegas, which has provided more than 100 people with free blood tests. "Their safe harbors no longer exist."

Nevada — whose population has more than doubled since 1990, to 2.5 million — has fewer physicians per 100,000 residents and a higher percentage of people without health insurance than many other states, according to the nonprofit United Health Foundation.

Recent checks of other medical centers have turned up more cases in which staff members allegedly reused syringes or vials, said Brian Labus, senior epidemiologist for the Southern Nevada Health District.

"It's important and big in that it should never have happened at all," said Dr. Michael Bell, associate director for infection control at the federal Centers for Disease Control and Prevention.

The CDC sent a team this past week to help Nevada officials inspect the state's 50 or so surgical centers. Political leaders are haggling over whether the facilities should be checked more frequently than once every three years, an idea Gov. Jim Gibbons recently compared to state troopers trying to catch every speeder.

Meanwhile, several law-enforcement agencies, including the FBI, are investigating the now-closed Endoscopy Center, and former patients have filed lawsuits against the center, its doctors and health officials.

Dr. Dipak Desai, the Endoscopy Center's majority owner, voluntarily agreed to stop practicing medicine while the state medical board conducts an investigation.

"As a longtime resident of Southern Nevada," Desai said in a statement, "I share our community's sorrow and concern for those who have been affected by this situation. ... These unfounded allegations will be addressed in a court of law, when facts have been presented and substantiated."

Officials have linked six hepatitis C cases to the center, and have issued a list of questions patients should ask their doctors. Among them: "Can you assure me that I am safe in your facility from the transmission of communicable diseases?"

"You have to wonder how much of the iceberg is showing," said Sally Hardwick, interim director of the Nevada Center for Ethics & Health Policy at the University of Nevada, Reno.

Substandard injection practices have led to 14 hepatitis outbreaks across the country since 1999, according to the CDC, including one last year in Michigan in which 13,000 dermatology patients were urged to seek testing.

Hepatitis C is a potentially fatal liver disease for which there is no cure; its symptoms include stomach pain, nausea, vomiting and jaundice. Treating a single case can cost $60,000 annually.