This chart shows the adverse drug reaction rate-per-million new prescriptions for the first year of the three most commonly prescribed benzodiazepines (sleeping agents) marketed in the United States.Dalmane Restoril Halcion 1970 1981 1983 Daytime sedation 19.5 4.0 15.5

Hyperexcitability 11.1 31.9 83.8

Amnesia 0.0 1.0 47.5

Cognitive disturbances and

psychotic symptoms 12.5 12.0 122.2

Affective and behavioral

disorders 2.8 7.0 25.5

Withdrawal and dependency 4.2 12.0 23.7

Other effects 21.0 7.0 81.2

Total reactions: 71.1 74.9 399.4

Lack of drug effect: 0.0 33.0 13.6

Source: "Adverse Reactions to Benzodiazepine Hypnotics: Spontaneous Reporting System," by Edwards O. Bixler, Anthony Kales, Barbara Brubaker, Joyce D. Kales, Sleep Research and Treatment Center and Department of Psychiatry, Pennsylvania State University College of Medicin, Hershey, Pa.