University of Utah researchers are looking for post-menopausal women to participate in a clinical trial of hormonal replacement therapy.

The drug therapy, part of a $50 million trial sponsored by Ayerst Laboratories, is designed to determine what combination and dosage of estrogen and progesterone are the most effective for post-menopausal women.Curent drug therapy includes a 25- to 30-day course of estrogen and 10 or 12 days of progesterone - a combination that causes some 70 percent of women to menstruate years after menopause.

Although the clinical trials are just beginning, the ultimate goal is to combine the two hormones into one pill, instead of what is now a complicated drug regimen.

To be eligible for the study, women must be 45 to 65 years old, not have had a hysterectomy and not have menstruated for at least 12 months. Participants must make a one-year commitment to the study, during which time they will make seven visits to University Hospital.

At the conclusion of the drug trial, which includes four different regimens all of which will be advantageous to participants, the women will receive $300.