The Trojans struggled offensively at the start of the game, but improved their shooting in the second half behind Byron Wesley, who scored all of his 13 points after halftime.
Also finishing with 13 points was USC forward Dewayne Dedmon, who added 13 rebounds and five blocks.
Utah forward Jarred DuBois had a game-high 18 points.
The 15-point loss is the Runnin' Utes' biggest defeat this season.
Whitney O'Bannon is currently a new media sports intern for the Deseret News.