Scherzer got one out in the seventh but left after walking rookie Xander Bogaerts to put runners on first and second. Drew Smyly got Jacoby Ellsbury to hit a grounder up the middle, but it popped out of Iglesias' glove behind second base and everyone was safe.
Veras came in and quickly got ahead of Victorino. But he hung a curveball and Victorino sent it toward the 37-foot left-field wall, which had already knocked down two Red Sox line drives.
This one left no doubt.
It was the second career postseason slam for Victorino, who also had a record-setting hit-by-pitch in the sixth but failed to get a bunt down in the third.
"He's come up big a number of times this season, none bigger," Farrell said. "Probably the last thing we're thinking of, that he's going to hit a ball out of the ballpark, and thankfully the curveball stayed (up)."
Scherzer and Clay Buchholz also matched up in Game 2, when the Tigers right-hander took a no-hitter and a 5-0 lead into the sixth. The Red Sox rallied against the Detroit bullpen, tying it on David Ortiz's eighth-inning grand slam and winning it in the ninth on Jarrod Saltalamacchia's walk-off single through a drawn-in infield.
Both starters gave up hits in the first inning in the rematch, but it remained scoreless until Bogaerts doubled off the Green Monster with two outs in the fifth and scored on Ellsbury's single.
But the Tigers took the lead in the bottom half, chasing Buchholz with a walk and Miguel Cabrera's single before Franklin Morales walked Prince Fielder on four pitches to load the bases with nobody out.
Victor Martinez lined one high off the Green Monster to make it 2-1, holding at first with a two-run single.
Brandon Workman came in and got Jhonny Peralta to hit a hard grounder to Pedroia, who chased down Martinez in the basepath for one out and then threw home to get Fielder in a rundown. Saltalamacchia ran him back to third and dove, somersaulting over him while making the tag.
Workman struck out Alex Avila looking to end the inning.
Scherzer worked out of a jam in the bottom half after putting runners on second and third with one out. He allowed three runs on four hits and five walks, striking out seven in 6 1-3 innings.
Buchholz gave up two runs on four hits and two walks, striking out four in five-plus innings.
Scherzer walked the first two batters in the third, but Victorino popped up a bunt and Scherzer made a sliding catch for the first out.
Pedroia hit a high drive that was just foul of the Carlton Fisk pole above the Green Monster. After it was confirmed by replay, he hit a hard grounder down the line that Cabrera fielded, easily stepping on third base before throwing to first for the double play.
NOTES: It will be the first World Series between the teams with the best record in each league since 1999. ... Detroit C Alex Avila, who absorbed a body shot and a foul ball off the mask in Game 5, took another ball off the mask in the fourth but remained in the game. ... The Dropkick Murphys sang the national anthem before the game, followed by "Shipping up to Boston," wearing Red Sox jerseys that said "Boston Strong" and the number 617. ... The Red Sox are 6-0 in Game 6 of the ALCS. ... Ellsbury had successfully stolen 18 bases in a row in the regular season and playoffs before being thrown out in the fifth. ... Victorino was hit by a pitch leading off the sixth, his sixth of the playoffs, extending his record and setting a major league record with the 10th postseason HBP of his career. Alex Rodriguez had the old record.
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