Romo was 36 of 49 for 263 yards, and Miles Austin had 10 catches for 72 yards. Witten, who had only three touchdowns last year, had eight grabs for 70 and became the third tight end in NFL history with 9,000 yards receiving. DeMarco Murray had 86 yards rushing for Dallas.
Romo threw a 15-yard TD pass to Witten before halftime, and Dan Bailey also had two field goals (30 and 38 yards) by then for a 13-10 lead.
In the final minute of the first half, Romo was hit in the ribs and had the wind knocked out after being crushed between Mathias Kiwanuka and Justin Trattou after throwing an incompletion. Kyle Orton came on to finish the half, but Romo was back after halftime.
Cowboys owner Jerry Jones said Romo didn't receive any treatment, and that the medical staff cleared him to play.
"One tough player, one tough man," Jones said. "He will go out and play in pain and play hurt."
After Manning's second interception, this one by new Cowboys safety Will Allen, Dallas had third-and-11 at the Giants 14.
Romo threw a pass toward rookie Terrance Williams that instead deflected off the Giants' Prince Amukamara into the arms of New York teammate Ryan Mundy, who raced 91 yards. He was caught from behind by Murray at the 1.
NOTES: The crowd of 85,348 was significantly smaller than the NFL regular-season record crowd of 105,121 that watched the first Giants game at the stadium in its 2009 debut. ... Giants CB Prince Amukamara was knocked out of the game with a concussion after a helmet-on-helmet collision with S Ryan Mundy, who was cleared to return.
AP NFL website: www.pro32.ap.org
Follow Schuyler Dixon on Twitter at https://twitter.com/apschuyler
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