Scientists: China bird virus likely silent threat

By Gillian Wong

Associated Press

Published: Wednesday, April 3 2013 7:30 a.m. MDT

A duck stands near a warning sign at an amusement park in Beijing, China, Wednesday, April 3, 2013. Scientists taking a first look at the genetics of the bird flu strain that recently killed two men in China said Wednesday the virus could be harder to track than its better-known cousin H5N1 because it might be able to spread silently among poultry without notice. The bird virus also seems to have adapted to be able to be able to sicken mammals like pigs.

Alexander F. Yuan, Associated Press

BEIJING — Scientists taking a first look at the genetics of the bird flu strain that recently killed two men in China said Wednesday that the virus could be harder to track than its better-known cousin H5N1 because it might be able to spread silently among poultry without notice.

The scientists, at several research institutes around the world, said the H7N9 virus seems troubling because it can generate no symptoms in poultry while seriously sickening humans. They said the virus, previously known to have infected only birds, appears to have mutated, enabling it to more easily infect other animals, including pigs, which could serve as hosts spreading the virus more widely among humans.

The findings are preliminary and need further testing. In the meantime, the scientists are urging Chinese veterinary authorities to widely test animals and healthy birds in affected regions to detect and eliminate the virus before it becomes widespread.

In addition to causing two deaths in Shanghai, the virus also seriously sickened five other people in two eastern provinces in the strain's first known infections of humans. Those regions stepped up measures this week to guard against the spread of the disease, calling on hospitals to report severe pneumonia cases with unknown causes and schools to monitor for fevers.

In the wake of the outbreak, the Chinese Center for Disease Control and Prevention shared the genetic sequence of the new virus with the global health community. The data allow scientists to make preliminary interpretations of how the virus might behave in different animals and situations. Such hypotheses, while not conclusive, can help provide important early warnings to authorities dealing with the disease.

The scientists said that based on information from the genetic data and Chinese lab testing, the H7N9 virus appears to infect some birds without causing any noticeable symptoms. Without obvious outbreaks of dying chickens or birds to focus efforts on, authorities could face a challenge in trying to trace the source of the infection and stop the spread.

"We speculate that when this virus is maintained in poultry the disease will not appear, and similar in pigs, if they are infected, so nobody recognizes the infection in animals around them, then the transmission from animal to human may occur," said Dr. Masato Tashiro, director of the World Health Organization's influenza research center in Tokyo and one of the specialists who studied the genetic data. "In terms of this phenomenon, it's more problematic."

This behavior is unlike the virus's more established relative, the virulent H5N1 strain, which set off warnings when it began ravaging poultry across Asia in 2003. H5N1 has since killed 360 people worldwide, mostly after close contact with infected birds.

"In that sense, if this continues to spread throughout China and beyond China, it would be an even bigger problem than with H5N1 in some sense, because with H5N1 you can see evidence of poultry dying, but here you can see this would be more or less a silent virus in poultry species that will occasionally infect humans," said University of Hong Kong microbiologist Malik Peiris, who also examined the information.

Scientists closely monitor bird flu viruses, fearing they may change and become easier to spread among humans, possibly sparking a pandemic. There's no evidence of that happening in China.

Peiris praised Chinese health authorities for being forthcoming with data and information, but said animal health agencies needed to step up and act quickly. He urged China to widely test healthy birds in live animal markets in the parts of the country where the human infections have been reported to find out what bird species might be hosting the virus and stop the spread.

"If you don't stamp it out earlier now, there won't be any chance of stamping it out in the future," Peiris said. "It already may be too late, but this is the small window of opportunity that really one has to grasp, as quickly as possible."

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