Jacksonville lost star running back Maurice Jones-Drew to a foot injury. Then quarterback Blaine Gabbert hurt his shoulder.
This was one rough day for the Jaguars.
Jones-Drew was on the field for just two snaps Sunday, carrying the ball on the first two plays at Oakland before leaving with an ailing left foot. When Gabbert departed midway through the second quarter, Jacksonville was in control of the game.
But the Jaguars managed only two downs after halftime behind backup quarterback Chad Henne went on to a 26-23 overtime loss.
The Redskins also lost a key player during a dramatic road loss.
Tight end Fred Davis tore his left Achilles tendon in the first half of Washington's 27-23 setback against the Giants. He needed help to the sideline and then onto a trainer's table before he was carted to the locker room.
"I didn't know what it was right away," said Davis, who will miss the rest of the season. "I have never experienced anything like that. I was unable to walk and then I knew something really was wrong.
"I was running my route and stuck my leg in and either got stepped on or it happened naturally."
Davis was the team's leading receiver with 23 catches for 312 yards entering Sunday's game.
"I had a lot of things I wanted to do this year and I was doing it," he said. "It's very discouraging."
Redskins linebacker London Fletcher, who has played in 231 successive games, left in the fourth quarter with a right hamstring injury. Coach Mike Shanahan called it a mild strain.
The status of Tennessee linebacker Zac Diles is uncertain after he hurt his right ankle and was carted off from the sideline during a 35-34 win at Buffalo.
Coach Mike Munchak would only say that Diles' injury initially appeared to be more serious than an injury sustained by reserve linebacker Patrick Bailey, who hurt his chest while covering a kickoff in the third quarter.
Diles was hurt while attempting to tackle running back C.J. Spiller on the Bills' first possession. Diles was leaning to his left when he lost his footing and his right ankle twisted beneath him.
Diles slowly limped off the field after being tended to by Titans trainers, and was then driven off from the sideline. He was starting in place of Colin McCarthy, who missed his fourth game with an ankle injury.
The Bills lost right guard Chad Rinehart early in the third quarter after he hurt his left ankle blocking during a run by Spiller. A Titans player fell on the back of Rinehart's leg, forcing Rinehart to be carted off the field.
Coach Chan Gailey had no update on Rinehart's status following the game. Buffalo was already minus starting offensive linemen Kraig Urbik (knee) and Cordy Glenn (knee).