Hundreds of Pakistanis, joined by dozens of American activists, have launched a motorcade "march" against U.S. drone strikes that they hope will reach the militant-riddled Afghan border region.

The main faction of the Pakistani Taliban has denounced the protest, and it is unclear how far the protesters will get.

The march — in reality a long vehicle convoy — is being led by Imran Khan, the former cricket star-turned-politician.

It began Saturday morning in Islamabad and is intended to end in South Waziristan tribal region, a frequent target of drone-fired American missiles.

The American activists are from the U.S.-based anti-war group CODEPINK.

Drone strike opponents allege such attacks kill numerous innocent civilians and terrorize peaceful communities. U.S. officials have said the majority of those killed in the strikes are militants.