Officials rushed to evacuate more than 100 nursing home residents from Plaquemines Parish, an area with a reputation for residents hunkering down to weather storms and perhaps the hardest hit by Isaac. In this hardscrabble, mostly rural parish, even the sick and elderly are hardened storm veterans.
"I don't think we had to evacuate to begin with," said Romaine Dahl, 59, as he sat in a wheelchair. "The weather was a hell of a lot worse last night than it is now. And I got an idea that after all this is said and done they're going to say everything is over with, go on back home."
Other residents in the Riverbend Nursing and Rehabilitation Center were loaded into ambulances and taken to a nearby naval station. Residents had their names and birth dates attached to their shirts.
Josephine King, 84, handled the move well, waiting in a wheelchair. "I'm feeling good," she said.
By midafternoon Wednesday, Isaac had been downgraded to a tropical storm. The Louisiana National Guard ceased rescue operations in Plaquemines Parish, saying it felt confident it had gotten everyone out. There were no serious injuries. National Guard spokesman Capt. Lance Cagnolatti said guardsmen would stay in the area over the coming days to help.
By early Thursday, Isaac's maximum sustained winds had decreased to 45 mph and the National Hurricane Center said it was expected to become a tropical depression by Thursday night, meaning its top sustained winds would drop below 39 mph. The storm's center was on track to cross Arkansas on Friday and southern Missouri on Friday night, spreading rain as it goes.
Forecasters expected Isaac to move farther inland over the next several days, dumping rain on drought-stricken states across the nation's midsection before finally breaking up over the weekend.
Even at its strongest, the storm was far weaker than Hurricane Katrina, which at its peak was a Category 5 and hit New Orleans as a Category 3. Isaac came ashore late Tuesday as a Category 1 hurricane, with 80 mph winds near the mouth of the Mississippi River. It drove a wall of water nearly 11 feet high inland. Because Isaac's coiled bands of rain and wind were moving at only 5 mph — about the pace of a brisk walk — the threat of storm surges and flooding was expected to linger Thursday as the immense system crawled across Louisiana.
The storm knocked out power to as many as 700,000 people, stripped branches off trees and flattened fields of sugar cane so completely that they looked as if a tank had driven over them.
In coastal Mississippi, officials used small motorboats Wednesday to rescue at least two dozen people from a neighborhood Isaac flooded in Pearlington. In addition, the National Weather Service said there were reports of at least three possible tornadoes touching down in coastal counties. No injuries were reported.
None of the reports had been confirmed. Until the weather clears, there is no way for survey teams to assess the area to determine whether damage was done by tornadoes or straight-line winds, said NWS Meteorologist Shawn O'Neil.
Back in New Orleans, the storm canceled remembrance ceremonies for those killed by Katrina. Since that catastrophe, the city's levee system has been bolstered by $14 billion in federal repairs and improvements. The bigger, stronger levees were tested for the first time by Hurricane Gustav in 2008.
In Vermilion Parish, a 36-year-old man died after falling 18 feet from a tree while helping friends move a vehicle ahead of the storm. Deputies did not know why he climbed the tree.
The storm stalled for several hours before resuming a crawl inland, and forecasters said that was in keeping with its erratic history. The slow motion over land means Isaac could be a major soaker, dumping up to 20 inches of rain in some areas. New Orleans reported at about 10 inches in some places as rain continued to fall late Wednesday.
As hard wind and heavy rain pelted Melba Leggett-Barnes' home in the Lower 9th Ward, an area leveled during Katrina, she felt more secure than she did seven years ago.
"I have a hurricane house this time," said Barnes, who has been living in her newly rebuilt home since 2008. She and her husband, Baxter Barnes, were among the first to get a home through Brad Pitt's Make It Right program.
Her yellow house with a large porch and iron trellis was taking a beating but holding strong.
"I don't have power, but I'm all right," said Barnes, a cafeteria worker for the New Orleans school system.
Contributing to this report were Associated Press writers Brian Schwaner and Stacy Plaisance in New Orleans; Melinda Deslatte in Baton Rouge; Kevin McGill in Houma; Holbrook Mohr in Waveland and Pass Christian, Miss.; and Jeff Amy in Biloxi and Gulfport, Miss.
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