The day's most dramatic match came on the Grandstand Court, where 68th-ranked Guillermo Garcia-Lopez came back against 10th-seeded Juan Monaco for a 3-6, 1-6, 6-4, 7-6 (6), 7-6 (3) victory that took 4 hours, 31 minutes.
"There's just this bitter taste right now, I feel awful," Monaco said. "I had my chances and I let the match slip away. I don't want to say that I had it in the pocket. But if you don't shut it down, you're leaving an opening to your opponent."
Later, Kiki Bertens of the Netherlands bounced 21st-seeded American Christina McHale 6-4, 4-6, 6-3.
Also falling was eighth-seeded Caroline Wozniacki, still slowed from a right knee injury she endured last week at the tournament in New Haven. She lost 6-2, 6-2 to 96th-ranked Irina-Camelia Begu of Romania and had little patience for a reporter who asked her how much the injury robbed her of her trademark side-to-side speed.
"I don't know," Wozniacki said. "I haven't really had a machine out there measuring."
On Tuesday, the most telling numbers were on the scoreboard, and those numbers did not lie.
Play in the main stadium began with second-seeded Agnieszka Radwanska's 6-1, 6-1 victory over Nina Bratchikova and ended less than 11 hours later with Williams beating Vandeweghe by the same score.
"Beatdown city so far on ASHE," former U.S. David Cup captain Patrick McEnroe tweeted at day's end. "Will it change tomorrow??"
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