"We're going to show the world on Tuesday, Wednesday and Thursday what a great place this is," he said. "As a state and a city, we're going to put on a good show and be a great host for the Republican Party."
As of 8 a.m. EDT Monday, the storm was centered about 185 miles (295 kilometers) west-southwest of Fort Meyers, Fla., and 360 miles (575 kilometers) southeast of the mouth of the Mississippi River, according to the National Hurricane Center in Miami. Isaac had top sustained winds of 65 mph (100 kph) and was moving west-northwest near 14 mph (22 kph).
Florida, historically the state most prone to hurricanes, has been hurricane-free since it was hit four times each in 2004 and 2005. Isaac will likely prove barely a memory for South Florida and Keys residents, who mostly took the storm in stride as its center passed just south of Key West on Sunday.
The storm did knock out power temporarily for around 16,000 customers throughout South Florida, and 555 flights were canceled at Miami International Airport. That forced some people to shuffle their travel plans and kept many, at least for a day, from enjoying their beach vacations.
In the low-lying Keys, isolated patches of flooding were reported and some roads were littered with downed palm fronds and small branches. But officials said damage appeared to be minimal, and many Keys residents held true to their any-excuse-for-a-party reputation.
The Gulf Coast hasn't been hit by a hurricane since 2008, when Dolly, Ike and Gustav all struck the region.
Before reaching Florida, Isaac was blamed for eight deaths in Haiti and two more in the Dominican Republic, and downed trees and power lines in Cuba. It bore down on the Keys two days after the 20th anniversary of Hurricane Andrew, which caused more than $25 billion in damage and killed 26 people in South Florida.
Associated Press writers Tony Winton in Key West, Melissa Nelson in Pensacola, Fla.; Mike Schneider in Tampa, Fla.; and Tim Reynolds, Curt Anderson and Suzette Laboy in Miami contributed to this report.
- Photo gallery: Night skies over national parks
- Ann Romney on likability, Hillary Clinton, MS...
- Rep. Jason Chaffetz says he wouldn't run...
- Does your child struggle to focus? Here's why...
- Is 'Speaker Chaffetz' more likely with...
- Strong emotions as Obama visits grieving...
- 'Historic' floods hit South Carolina —...
- How your bedtime can affect your weight
- Is 'Speaker Chaffetz' more likely with... 69
- Workers removing Ten Commandments from... 56
- Chaffetz's run for speaker makes... 47
- Mother-son bond over guns links Oregon,... 22
- 40 percent tax on employer insurance... 22
- Clinton pitches new gun controls... 16
- Obama touts immigration reform in... 16
- Judge dismisses negligence lawsuit... 15