BEIRUT — Rebels penetrated the heart of Syria's power elite Wednesday, detonating a bomb inside a high-level crisis meeting in Damascus that killed three leaders of the regime, including President Bashar Assad's brother-in-law and the defense minister.
The unprecedented blow to the ruling dynasty could mark a turning point in the civil war, suggesting that those once close to Assad are turning against him. The bombing follows some of the worst bloodshed in Damascus of the 16-month uprising, a growing list of high-ranking defections and mounting frustration by world leaders over their inability to find a diplomatic solution.
The White House said the bombing showed Assad was "losing control" of Syria.
Rebels claimed responsibility for the attack, saying they had been planning it for two months and finally decided to plant the bomb in the room where the top government security officials in charge of crushing the revolt were holding a crisis meeting.
"God willing, this is the beginning of the end of the regime," said Riad al-Asaad, a commander of the disparate rebel forces who operate across the country. Al-Asaad, who is not related to the president, spoke to The Associated Press by telephone from Turkey, where he is based.
"Hopefully Bashar will be next," Al-Asaad said in a chilling warning to the 46-year-old Syrian president, a tall, lanky leader who once felt so confident in his security that he was known to hate being surrounded by bodyguards.
The whereabouts of Assad, his wife and his three young children were not immediately clear. He gave no immediate statements on the attack, which state-run TV initially blamed on a suicide bomber but later called simply a bomb.
As news of the assassinations broke, Syrians opposed to Assad celebrated in several locations across the country.
Internet video showed people in convoys of cars and motorbikes honking their horns and firing weapons in the air in the northeastern Idlib province, along with Aleppo in the north, Daraa in the south and Homs in central Syria. In the village of Hass, residents distributed sweets as they gleefully shouted: "You are going to hell, shabihas" — a reference to the pro-regime militia that has been blamed for mass killings.
The AP could not immediately verify the authenticity of the video.
Syrian TV confirmed the deaths of Defense Minister Dawoud Rajha, 65, a former army general and the most senior government official to be killed in the rebels' battle to oust Assad; Gen. Assef Shawkat, 62, the deputy defense minister who is married to Assad's elder sister, Bushra, and is one of the most feared figures in the inner circle; and Hassan Turkmani, 77, a former defense minister who died of his wounds in the hospital.
Also wounded were Interior Minister Mohammed Shaar and Maj. Gen. Hisham Ikhtiar, who heads the National Security Department. State TV said both were in stable condition.
Rajha was the most senior Christian government official in Syria, appointed to the post by Assad last year. His death will resonate with Syria's Christians, who make up about 10 percent of the population of 22 million and have mostly stood by the regime.
Christians say they are particularly vulnerable and they fear that Syria will become another Iraq, with Christians caught in the crossfire between rival Muslim groups.
The attack came at a time of great momentum for the forces trying to oust Assad, whose family has ruled Syria for four decades. Although the uprising began in March 2011, recent weeks have seen a spike in potentially transformative events, including high-level defections from the regime.
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