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Tony Dejak, Associated Press
Cleveland Indians' Carlos Santana hits an RBI-single off Chicago White Sox starting pitcher Chris Sale in the sixth inning in a baseball game Monday, April 9, 2012, in Cleveland. Shin-Soo Choo scored.

CLEVELAND — Chris Sale won his first career start, limiting Cleveland to one run in 6 2-3 innings and leading the Chicago White Sox to a 4-2 win over the Indians on Monday night.

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Sale pitched out of Chicago's bullpen the past two seasons but moved into the rotation after ace Mark Buehrle left as a free agent this winter. The left-hander, who had made 79 relief appearances, took a one-hit shutout into the sixth. In his longest outing, Sale allowed three hits and struck out five.

The 23-year-old had little trouble with a Cleveland team that came in batting .153.

Rookie Hector Santiago gave up Jose Lopez's homer in the ninth before getting his second save.

A.J. Pierzynski hit a two-run homer in the first, four batters after Alejandro De Aza homered leading off against Josh Tomlin (0-1).