With 100 days until this year's European Championship, Italy lost to the United States for the first time in 11 games over 78 years, while Spain, France and the Netherlands prepared with impressive wins.
Clint Dempsey scored in the 55th minute at Genoa, and the Americans held on for a 1-0 victory Wednesday night that gave them a rare win over a world power.
Roberto Soldado had a hat trick to lead defending European champion Spain to a 5-0 win over Venezuela in Malaga. France extended its unbeaten run to 18 matches as Oliver Giroud and Florent Malouda scored in a 2-1 victory over Germany in Bremen.
The Netherlands won 3-2 at England when Arjen Robben scored his second goal of the game in stoppage time. That gave Stuart Pearce a loss in his first game as England's interim coach.
Saudi Arabia was eliminated from Asian qualifying for the 2014 World Cup with a 4-2 loss at Australia, while South Korea, Lebanon, Oman and Qatar advanced to the final round.