NEW ORLEANS — The Saints moved to 8-0 for the first time in club history when Drew Brees overcame two early turnovers to pass for 330 yards and a touchdown.

While the Saints' defense did not intercept a pass for the first time all season, the unit forced three turnovers on fumbles. The last produced New Orleans' seventh defensive touchdown of the season on Anthony Hargrove's strip, recovery and 1-yard return late in the fourth quarter.

DeAngelo Williams rushed for 149 yards and two TDs, and Carolina gained 182 on the ground. However, it was Williams' fumble at his 1 with just more than 2 minutes left that led to New Orleans' clinching TD.

It was the first time Carolina lost in Louisiana since 2001 and quarterback Jake Delhomme's first loss in the Louisiana Superdome. The Panthers blew a 17-3 lead.

COLTS 20, TEXANS 17: At Indianapolis, running back Joseph Addai scored the go-ahead touchdown with 7:11 left and Houston's Kris Brown missed a 42-yard field goal as time expired, keeping Indianapolis undefeated.

Indy is the fourth team in league history with 17 straight wins. New England has done it twice and Chicago did it in 1933-34. Jim Caldwell became the first rookie coach to go 8-0 since Potsy Clark in 1930.

TITANS 34, 49ERS 27: At San Francisco, six plays after his 81-yard touchdown run was overturned, Chris Johnson took a pitch from Vince Young and ran 2 yards for a go-ahead score. Young showed his comeback is legitimate, outplaying fellow first-round draft pick Alex Smith down the stretch. Young has been clutch twice in as many weeks, getting the Titans (2-6) in the end zone when it mattered. Johnson converted on fourth-and-inches for his TD, making up for those six points negated only a few minutes earlier after video replay determined he stepped out of bounds on the long run.

PATRIOTS 27, DOLPHINS 17: At Foxborough, Mass., Tom Brady and Randy Moss connected on two highlight-reel plays. Moss set up the Patriots' first touchdown with a one-handed, 36-yard grab at the Dolphins 1-yard line, then scored on a 71-yard play after catching the ball about 10 yards beyond the line of scrimmage. Miami's touchdowns came on possessions on which it used the wildcat most extensively — gaining just 36 yards on 21 wildcat plays in its previous two games.