NFL roundup: Cards wipe out Bills' record

GLENDALE, Ariz. — The Bills lost their quarterback and, emphatically, their first game of the season.

Second-year quarterback Trent Edwards, a major reason Buffalo was one of three unbeaten teams entering the day, went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game. The Bills' defense collapsed after that.

Rookie Tim Hightower had a pair of touchdown runs and Kurt Warner threw to Larry Fitzgerald twice for scores. Warner, who committed six of Arizona's seven turnovers in last week's loss at the Jets, bounced back to go 33-of-42 for 250 yards with no interceptions. The Cardinals (3-2) are 3-0 at home.

Without standout receiver Anquan Boldin (head injury), Arizona amassed 373 yards against what had been one of the stingier defenses in the league. Buffalo's offense contributed, too, fumbling three times in Bills territory, resulting in 17 Arizona points.

J.P. Losman, who wanted an offseason trade after losing his job to Edwards, was 15-of-21 for 220 yards, most of them on an 87-yard touchdown pass to Lee Evans.

BRONCOS 16, BUCCANEERS 13: At Denver, the high-flying Broncos finally discovered a defense, generating a pass rush that sent Brian Griese to the sideline with an injured throwing shoulder. Jay Cutler guided a patient Denver offense over the Buccaneers (3-2). Brandon Stokley hauled in Cutler's pass in the right flat and followed Brandon Marshall's big block for a 10-yard touchdown and Matt Prater kicked three field goals for Denver. Griese, making his first visit to Invesco Field since his five frustrating years in Denver as John Elway's successor, never looked at Champ Bailey barreling in on him from his right side. Griese was smothered at the goal line just as he released the ball late in the third quarter.

Griese was replaced by the more mobile Jeff Garcia, the man he supplanted after a loss to New Orleans in the opener. But Garcia had only slightly more success against the Broncos (4-1), who also hounded him, knocking him down several times.

COWBOYS 31, BENGALS 22: At Irving, Texas, after letting a 17-point lead shrivel to one, then breaking up a 2-point conversion that could've tied it, the Cowboys had plenty of reasons to celebrate. Dallas (4-1) led 17-0 after only three drives but ended up needing big plays from Terrell Owens, Tank Johnson and Keith Davis to stave off the bumbling Bengals (0-5). Tony Romo was 14-of-23 for a season-low 176 yards but threw three touchdown passes — two in the fourth quarter. He also threw another interception, making it eight straight games, lost a fumble and was out of sync with T.O. until a 57-yard TD hookup in the fourth period.