Wade Payne, Associated Press
NASHVILLE, Tenn. — New Orleans got a wake-up call from the Tennessee Titans and Drew Brees came through to keep the Saints' winning streak going.
Unable to reach the end zone through three quarters, the Saints got a pair of touchdown passes from Brees to Marques Colston in the final 15 minutes to beat the Titans 22-17 on Sunday.
"It was a gut-check win for us," New Orleans coach Sean Payton said. "A lot of things early on didn't go our way. We had some calls that could have went either way. We just kept fighting and won a good game on the road against a good team."
Now the Saints (10-3) have won five straight and remain in the lead of the NFC South with three games left in the regular season. They clinched a playoff berth when the Chicago Bears lost in overtime to the Denver Broncos later Sunday.
They got another strong performance from Brees, who joined Hall of Famer Johnny Unitas as the only quarterbacks to throw a touchdown pass in 40 straight games.
On third-and-6, Brees threw 35 yards to a wide-open Marques Colston, who jumped into the air just in front of the goal line at the middle of the field, caught the ball and fell forward into the end zone, making it 16-10 with 12:39 to play.
The Saints converted two third downs on their next drive before Brees connected again with Colston on a scoring pass, this time for 28 yards.
The touchdown gave New Orleans a 22-10 lead with 7:01 left, and Colston finished with 105 yards on seven catches.
"We knew they were going to get yards," Tennessee safety Michael Griffin said. "Drew knows how to dissect a defense."
Brees was 36 for 47 for 337 yards and completed passes to nine different Saints. He has 39,413 yards passing in 150 career starts, which ranks just behind the 39,498 yards passing Dan Marino achieved in his first 150 starts.
The Titans (7-6) twice had the ball in the final minutes with a chance to win.
Their loss allowed the Houston Texans, which won at Cincinnati on Sunday, to clinch the AFC South and kept them from gaining any ground in a crowded race for the second AFC wild-card spot.
"As bad as this one's going to hurt ... we can't let this one cost us anymore games," Titans coach Mike Munchak said. "We have three games, we have to win all three games."
Jake Locker hit Nate Washington on an 18-yard pass on second down, and Chris Johnson ran 3 yards around the left end to convert a fourth-and-1 to keep the drive alive.
Faced with another fourth down at the Saints 24 with 2:18 left, Locker kept the ball. Though a replay seemed to show he picked up the needed yard, the officials ruled him down with no gain, and the Titans did not challenge the ruling.
Tennessee held New Orleans on the next drive, and Washington caught a 40-yard pass from Locker with 27 seconds left, setting up another chance for a Titans rally.
Locker spiked the ball at the Saints 5 to stop the clock, but his pass on second down to Marc Mariani in the end zone was batted down by Tracy Porter, and Jo-Lonn Dunbar sacked a scrambling Locker on third down as time expired.
"I was just hoping they didn't throw a flag. I kind of grabbed him by the helmet," Dunbar said. "It was definitely a lot of relief to see those guys jumping, and with that excitement, you can't put a price tag on that."
The rookie quarterback entered the game with the score 3-3 with 11:13 left in the second quarter, replacing Matt Hasselbeck.
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