Speaking Friday on CBS' "The Early Show," North Carolina Gov. Beverly Perdue said state troopers, the Red Cross and the National Guard were in place to deal with the storm's aftermath, which she said could affect some 3.5 million people.
North Carolina was just first in line along the Eastern Seaboard — home to some of the nation's priciest real estate.
Besides major cities, sprawling suburbs, ports, airports, highways, cropland and mile after mile of built-up beachfront neighborhoods are in harm's way. In several spots along the coast, hospitals and nursing homes worked to move patients and residents away from what could be the strongest hurricane to hit the East Coast in seven years.
The center of the storm was still about 300 miles (483 kilometers) south-southwest of Cape Hatteras, N.C., and moving to the north at 14 mph (22 kph). Forecasters warned wind-whipped water could create a dangerous storm surge, with levels along the state's Albemarle and Pamlico sounds rising as much as 11 feet.
The latest forecasts showed Irene crashing into the North Carolina coastline Saturday, then churning up the Eastern Seaboard and drenching areas from Virginia to New York City before a weakened storm reaches New England.
In Washington, Irene dashed hopes of dedicating a 30-foot sculpture to Martin Luther King Jr. on Sunday on the National Mall. While a direct strike on the nation's capital appeared slim, organizers said forecasts of wind and heavy rain made it too dangerous to summon a throng they expected to number up to 250,000.
The city of Alexandria, Va., just outside Washington ran out of the free sandbags provided to residents at three distribution centers, though officials hoped to have more later Friday.
In nearby McLean, shoppers crowded into grocery and hardware stores to stock up on food, flashlights, gas cans, drills, coolers and wet vacs. McLean Hardware employee John Crawford said the last-minute shopping didn't compare to the rush before the massive snowstorm that hit the D.C. area in February 2010.
"This is not that bad at all," he said.
In the Sandbridge section of Virginia Beach, Va., rental companies raced to evacuate guests and board up rental homes.
John Landbeck of Aberdeen, Md. spent Friday morning packing up the vacation home he was renting and pulling his fishing boat out of the water. He planned to ride out the storm at a hotel in Chesapeake and return to his rental for another two weeks once the storm passed. He said he'd stay out of harm's way but was taking things in stride.
"Hopefully we won't have any earthquakes, no more hurricanes, no more floods. But It's been fun. For me, life is an adventure. Whatever comes, we take it," he said.
More than a quarter-million New Yorkers were ordered to evacuate the city's low-lying coastal areas Friday. The transit system in the city — where few people have a car — would shut down around noon Saturday, the first time the entire system has ever been halted. A hurricane warning has not been issued for the nation's biggest city since Hurricane Gloria hit in 1985 as a Category 2 storm, said Ashley Sears, a meteorologist with the National Weather Service.
Even if the winds aren't strong enough to damage buildings in a metropolis made largely of brick, concrete and steel, a lot of New York's subways and other infrastructure are underground, making them subject to flooding.
Philadelphia officials also planned to shut down the city's transit system early Sunday morning.
New York's two airports are close to the water and could be inundated, as could densely packed neighborhoods, if the storm pushes ocean water into the city's waterways.
In the last 200 years, New York has seen only a few significant hurricanes, and New England is unaccustomed to direct hits. In 1938, a storm dubbed the Long Island Express came ashore about 75 miles east of the city and then hit New England, killing 700 people and leaving 63,000 homeless.
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