For a while, mealtime for Ashley Zundel, 9, consisted solely of turkey, rice, rice milk, potatoes and apple juice a shrinking menu that eliminated peanuts, milk, eggs, soy, corn, then sunflower seeds and pizza and celery.
Recently, she had to give up those five foods. She now relies on a feeding tube for nutrition.
The problem is eosinophilic gastroenteritis, which affects her stomach, intestine and colon, according to her parents, Dallyn and Tammy Zundel, of Orem.
Eosinophils are the smallest group of white blood cells, important for their battle against parasites in particular. They are named after the Greek god of dawn, Eos, because they turn bright pink-red when stained for viewing with a microscope.
In people with eosinophilic disorders, the number of the cells greatly increases, causing inflammation and related problems. Many of them also have asthma or eczema, although Ashley has neither.
Her brother, Preston, 7, has a milder form that affects only his colon, called eosinophilic colitis. He also has asthma.
There are a number of eosinophil-associated gastrointestinal disorders, according to the American Partnership for Eosinophilic Disorders (www.apfed.org). What you have depends on where the eosinophils are elevated. And true diagnosis can only be made by endoscopy and biopsy.
Dr. Gerald Gleich, a professor of dermatology and medicine at the University of Utah and a self-described "eosinophilomaniac" with more than 600 articles published on the topic, describes symptoms that include nausea, vomiting, abdominal pain, urgency to go to the bathroom and more. As it goes along, the intestine can "be afflicted to the point where it begins to leak protein. Ordinarily, the intestine is a one-way street, absorbing things."
The prolonged inflammation leads to less effective absorption and protein leakage. The most common treatment, once the diagnosis is confirmed by elevation in the number of blood eosinophils, is corticosteroids, which can "stop it in its tracks. In the short run, it's wonderful. But unless you understand what's going on, the short run becomes the long run," Gleich says. Long-term steroid use brings a "passel of difficulties," including cataracts, thinning of bones and skin, high blood pressure, weight gain and more.
Food-allergy tests help guide treatments, and certain foods may be eliminated. Doctors sometimes prescribe an "elemental diet," with no proteins or complex carbohydrates. An elemental diet has, instead, monosaccharides, very simple fats.
"It's not something you sit down with friends and chew and eat with a fork. You drink it" or receive it through a feeding tube. But often people weary of no food and go back on steroids.
Not all people with a form of eosinophilic disorder respond to the same treatment. There's great variation in both the degree of symptoms and the response to treatment.
The condition is not inherited. It can wax and wane. Sometimes food allergies are easy to spot; other times, there's no evident allergy at all. Many of the patients with an eosinophilic condition have allergies, hay fever, asthma, chronic hives, gastric reflux or atopic dermatitis, "a mark of the propensity of their immune system to react to things."
Those conditions can also wax and wane. If it becomes persistent, Gleich says, it's a considerable problem.
A human antibody mepolizumab taken intravenously shows promise of eliminating or reducing the need for corticosteroid treatment. But it's still in the study stage.
The most common form that Dr. Molly O'Gorman, an associate professor of pediatrics and a practitioner at Primary Children's Medical Center, sees is eosinophilic esophagitis.
- Target apologizes, takes down images of...
- Viral video: Mom gives 3-year-old a chance to...
- Wright Words: Disney's 'Frozen' and why we...
- 'Princeton Mom' releases self-help book on...
- In the Whirled: Has Pinterest sapped our...
- High teen suicide rates raise alarm on...
- 'Noah' banned in three countries weeks before...
- 'Humans of New York' author and girlfriend...
- Wright Words: Disney's 'Frozen' and why... 29
- 'Noah' banned in three countries weeks... 21
- Instead of 'Game of Thrones,' there are... 11
- Joseph Cramer, M.D.: Save the world,... 11
- Expose kids to diversity 5
- Target apologizes, takes down images of... 5
- Man killed in avalanche had a passion... 4
- Boys suffering from body image concerns 4