Reeve's support of stem cell research helped it emerge as a major campaign issue between President Bush and John Kerry. His name was even mentioned by Kerry earlier this month during the second presidential debate.

As for the strain of traveling to Hollywood, Reeve said: "I refuse to allow a disability to determine how I live my life. I don't mean to be reckless, but setting a goal that seems a bit daunting actually is very helpful toward recovery."

His athletic, 6-foot-4-inch frame and love of adventure made him a natural, if largely unknown, choice for the title role in the first "Superman" movie in 1978. He insisted on performing his own stunts.

Although he reprised the role three times, Reeve often worried about being typecast as an action hero.

"Look, I've flown, I've become evil, loved, stopped and turned the world backward, I've faced my peers, I've befriended children and small animals and I've rescued cats from trees," Reeve told the Los Angeles Times in 1983, just before the release of the third "Superman" movie. "What else is there left for Superman to do that hasn't been done?"

Though he owed his fame to it, Reeve made a concerted effort to, as he often put it, "escape the cape." He played an embittered, crippled Vietnam veteran in the 1980 Broadway play "Fifth of July," a lovestruck time-traveler in the 1980 movie "Somewhere in Time," and an aspiring playwright in the 1982 suspense thriller "Deathtrap."

"After the first 'Superman,' I had the compulsion to do parts that were really weird," Reeve told The Associated Press in 1987. "That freaked people out. I've passed that."

More recent films included John Carpenter's "Village of the Damned," and the HBO movies "Above Suspicion" and "In the Gloaming," which he directed. Among his other film credits are "The Remains of the Day," "The Aviator," and "Morning Glory."

Yet Reeve always will be known to movie fans as the strapping, boyishly handsome stage veteran whose charm and humor brought a new dimension to the characters of Superman and his alter-ego, Clark Kent. The film co-starred Margot Kidder as Lois Lane.

Reeve said in public appearances promoting the "Superman" films, he tried to get children to better themselves.

"They should be looking for Superman's qualities — courage, determination, modesty, humor — in themselves rather than passively sitting back, gaping slack-jawed at this terrific guy in boots," Reeve said.He in around 10 when he made his first stage appearance — in Gilbert and Sullivan's "The Yeoman of the Guard" at McCarter Theater in Princeton, N.J.

He starred in virtually all of the theatrical productions at the exclusive Princeton Day School. By age 16, he had joined the actors' union.