PESHAWAR, Pakistan — A suicide bomber in a pickup truck attacked the northwestern regional headquarters of the Pakistani spy agency overseeing a campaign against militancy, killing 10 people Friday. Another suicide assault in the area killed six more.

The bombings were the latest in a string of attacks on security forces, civilians and Western targets since the government launched an offensive in mid-October against militants in the border region of South Waziristan, where al-Qaida and Taliban leaders are believed to be hiding out.

The attack on the Inter-Services Intelligence agency building occurred in the city of Peshawar, which has borne the brunt of the militants' retaliation against the army offensive. A wave of bombings in the last week alone in and around the city has killed more than 50 people.

"This is a guerrilla war," said Mian Iftikhar Hussain, the information minister for North West Frontier Province, where Peshawar is the capital. "We will continue our action against these militant terrorists. That is the only way we can survive."

Security forces guarding the intelligence complex opened fire on a pickup laden with explosives, but the bomber was able to detonate his payload, said an intelligence official, speaking on condition of anonymity because he was not authorized to talk to the media.

The early morning blast, heard across the city, destroyed much of the three-story building and killed 10 people, including seven who worked for the spy agency, the army said in a statement. Another 55 people were wounded, officials said.

"I was going to work when the blast took place and shattered the windows of our vehicle," said witness Abdul Rahim Khan. "Thank God we are safe. There were a lot of dead bodies lying around."

About an hour later, a second suicide car bomber attacked a police station farther south near the Afghan border, killing six people, said police official Tahir Shah. Five of the dead were policemen working at the station in Bakkakhel village in Bannu district; the other was a civilian. Another 27 people were wounded, he said.

The station is close to the border with North Waziristan, an area in Pakistan's semiautonomous tribal region where officials believe many militants have fled to escape the recent army offensive.

The bombings took place as U.S. National Security Adviser Gen. James Jones visited the country for talks with top political and security officials, including military chief Gen. Ashfaq Parvez Kayani.