Windpipe rebuilt with patient's stem cells
"This technique has great promise," said Dr. Eric Genden, who did a similar transplant in 2005 at Mount Sinai Hospital in New York. That operation used both donor and recipient tissue. Only a handful of windpipe, or trachea, transplants have ever been done.
If successful, the procedure could become a new standard of treatment, said Genden, who was not involved in the research.
The results were published online Wednesday in the medical journal, The Lancet.
The transplant was given to Claudia Castillo, a 30-year-old Colombian mother of two living in Barcelona, who suffered from tuberculosis for years. After a severe collapse of her left lung in March, Castillo needed regular hospital visits to clear her airways and was unable to take care of her children.
Doctors initially thought the only solution was to remove the entire left lung. But Dr. Paolo Macchiarini, head of thoracic surgery at Barcelona's Hospital Clinic, proposed a windpipe transplant instead.
Once doctors had a donor windpipe, scientists at Italy's University of Padua stripped off its cells, leaving a tube of connective tissue.
Meanwhile, doctors at the University of Bristol took a sample of Castillo's bone marrow from her hip. They used the bone marrow's stem cells to create millions of cartilage and tissue cells to cover and line the windpipe.
Experts at the University of Milan then used a device to put the new cartilage and tissue onto the windpipe. The new windpipe was transplanted into Castillo in June.
"They have created a functional, biological structure that can't be rejected," said Dr. Allan Kirk of the American Society of Transplantation. "It's an important advance, but constructing an entire organ is still a long way off."
So far, Castillo has shown no signs of rejection and is not taking any immune-suppressing drugs, which can cause side effects like high blood pressure, kidney failure and cancer.
"I was scared at the beginning," Castillo said in a press statement. "I am now enjoying life and am very happy that my illness has been cured."
Her doctors say she is now able to take care of her children, and can walk reasonable distances without becoming out of breath. Castillo even reported dancing all night at a club in Barcelona recently.
Genden said that Castillo's progress needed to be closely monitored. "Time will tell if this lasts," he said. Genden added that it can take up to three years to know if the windpipe's cartilage structure is solid and won't fall apart.
People who might benefit include children born with defective airways, people with scars or tumours in their windpipes, and those with collapsed windpipes.
The technique might even be adapted to other organs like the bowel, bladder, or reproductive tract, Birchall said.
"Patients engineering their own tissues is the key way forward," said Dr. Patrick Warnke, a surgeon at the University of Kiel in Germany. Warnke is also growing patients' tissues from stem cells for transplants.
Warnke predicted that doctors might one day be able to produce organs in the laboratory from patients' own stem cells. "That is still years away, but we need pioneering approaches like this to solve the problem," he said.
Comments
- Attempted murder case refiled 1:58 a.m.
- Sports on the air 1:38 a.m.
- This weekend on TV 1:38 a.m.
- Birthdays for Saturday, July 11 1:38 a.m.
- 2 men cited on LDS plaza 1:37 a.m.
- S.L. man spots stolen car — his 1:23 a.m.
- Girl critical after run-in with train 1:23 a.m.
- Probe of death treated as slaying 1:22 a.m.
- Taylorsville man arrested in robbery 1:21 a.m.
- HBO defends U. logo use in 'Love' 1:20 a.m.
- Jazz brass debate Millsap match
- LDS seminary principal arrested
- 2 men cited on LDS plaza
- Reactions on Boozer speculation
- Teacher faces new sex charges
- HBO defends U. logo use in 'Love'
- Jazz finances not quite so bleak
- Jazz talking Boozer trade?
- S.L. man spots stolen car — his
- Jazz down Oklahoma City
- LDS seminary principal arrested
160 - Bronco collecting a galaxy of recruits
141 - Jazz talking Boozer trade?
136 - Blazers may offer Millsap a contract
123 - Jazz brass debate Millsap match
99 - Stadium of Fire flag burning was fake
94 - Fairness of BCS debated
81 - Chaffetz eyes challenging Bennett
74 - Letters: Single-payer system best
72 - Services bids farewell to Jackson
70
By now you've probably read about the investigation that showed just how...
Here's BYU's press release on Jonathan Tavernari's big game for the...
I love Millsap, and the Jazz will find a way to move Boozer and match for...
i think its childish to assume that somebody would actually want to get...
Millsap and Boozer need to stay in Utah. Millsap is Boozers backup while he...
Childish and immature? Its always easier being ignorant and presuming things...
can you use words like testimony and church leadership to critisize a...
Bro P really helped me through a tough time in my life when I had him in...
These are only allegations at present, but I hope when he goes to trial, the...
My thoughts are with the Pratt family right now. Michael I hope you are...
It is interesting that everyone who seems to be a member comments on how nice...
You presume, simply because they were gay, that they were trying to "stir...


You can be the first to comment on this story.