Anti-smoking pill may curb urge to drink

Published: Tuesday, July 10, 2007 12:35 a.m. MDT
 |  E-MAIL | PRINT | FONT + - 
WASHINGTON — A single pill appears to hold promise in curbing the urges to both smoke and drink, according to researchers trying to help people overcome addiction by targeting a pleasure center in the brain.

The drug, called varenicline, already is sold to help smokers kick the habit. New but preliminary research suggests it could gain a second use in helping heavy drinkers quit, too.

Much further down the line, the tablets might be considered as a treatment for addictions to everything from gambling to painkillers, researchers said.

Several experts not involved in the study cautioned that there is no such thing as a magic cure-all for addiction and that varenicline and similar drugs may find more immediate use in treating diseases like Alzheimer's and Parkinson's.

Pfizer Inc. developed the drug specifically as a stop-smoking aid and has sold it in the United States since August under the brand name Chantix. Varenicline works by latching onto the same receptors in the brain that nicotine binds to when inhaled in cigarette smoke, an action that leads to the release of dopamine in the brain's pleasure centers. Taking the drug blocks any inhaled nicotine from reinforcing that effect.

Story continues below

A study published Monday suggests not just nicotine but alcohol also acts on the same locations in the brain. That means a drug like varenicline, which makes smoking less rewarding, could do the same for drinking. Preliminary work, done in rats, suggests that is the case.

"The biggest thrill is that this drug, which has already proved safe for people trying to stop smoking, is now a potential drug to fight alcohol dependence," said Selena Bartlett, a neuroscientist with the Ernest Gallo Clinic and Research Center at the University of California, San Francisco who led the study. Details appear this week in the journal Proceedings of the National Academy of Sciences.

Pfizer provided the drug for the study but was not otherwise involved in the research.

More often than not, smoking and drinking go together — an observation pub-goers have made for hundreds of years. That a single drug could work to curb both addictions isn't a given — nor is it surprising, said Christopher de Fiebre, an associate professor of pharmacology and neuroscience at the University of North Texas Health Science Center at Fort Worth.

"This is an extremely important paper and hopefully it will convince the major funding agencies that they need to examine the interactions between nicotine and alcohol to a greater extent than they have done to date," said de Fiebre, who was not connected with the study.

In fact, the California researchers, together with the National Institute on Alcohol Abuse and Alcoholism, are now planning the first studies in humans of the drug's effectiveness in curbing alcohol cravings and dependence, Bartlett said. That the drug is already Food and Drug Administration-approved should speed things along.

Comments

You can be the first to comment on this story.

previousnext

Latest comments

Blazers get the unbalanced trade they seek while not signing Millsap away...

Ricky Bobby - THE JAZZ DO NOT WANT TO TAKE BACK EQUAL SALARIES. They want to...

Owls need holes for nest

Despite the fact that logging has all but stopped in the pacific northwest...

My understanding of what FAIR is trying to do, is to provide well thought out...

Jazz will resign Milsap. If they don't it will be ahuge mistake. First off,...

Stadium of Fire flag burning was fake

I was waiting for it to be burned on the big metal structure right by the...

Hey Ute fan... the Utes had a good season. And keep throwing that BCS bowl...

Tyrus Thomas is in the last year of his contract too so what is the point for...

CougarKeith, people don't know how to properly retire the flag, what they did...

It is just talk but since it was brought up: IF we can get Prizbilla &...

Advertisements