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Snuppy, the first cloned puppy

S. Korean scientists say creation will help in human disease research

Published: Thursday, Aug. 4, 2005 9:02 a.m. MDT
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He could be just another frisky, long-haired puppy with a slightly dazed expression. But his genetic fingerprint says otherwise.

Meet Snuppy, the world's first cloned dog. Scientists duplicated this Afghan hound, born 14 weeks ago, using a skin cell plucked from another hound. The two dogs are three years apart but genetically identical, right down to their weird, tan eyebrows.

Snuppy was created by South Korea's pioneering stem cell scientist, smashing another biological barrier and reigniting a fierce ethical debate.

The researchers, led by Hwang Woo-suk, insist they cloned the Afghan hound, a resplendent supermodel in a world of mutts, only to help investigate human disease, including the possibility of cloning stem cells for treatment purposes.

The dog's appearance in Thursday's issue of the journal Nature stirred renewed calls for a global ban on the cloning of humans to produce babies.

"Successful cloning of an increasing number of species confirms the general impression that it would be possible to clone any mammalian species, including humans," said Ian Wilmut, a reproductive biologist at the University of Edinburgh who produced the first cloned mammal, Dolly the sheep, from an adult cell nearly a decade ago.

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Researchers have since cloned cats, goats, cows, mice, pigs, rabbits, horses, deer, mules and gaur, a large wild ox of Southeast Asia. So far, efforts to clone a monkey or another primate with the same techniques have failed.

Uncertainties about the health and life span of cloned animals persist; Dolly died prematurely in 2003 after developing cancer and arthritis.

Wilmut and others complimented Hwang's achievement. But they said politicians and scientists must face the larger and more delicate issue — how to extend research without crossing the moral boundary of duplicating human life in the lab.

"The ability to use the underlying technology in developing research models and eventually therapies is incredibly promising," said Robert Schenken, president of the American Society for Reproductive Medicine. "However, the paper also points out that in dogs as in most species, cloning for reproductive purposes is unsafe."

The cloned puppy was the lone success from more than 100 dogs implanted with more than 1,000 cloned embryos.

In a news conference in Seoul, the cloning team also condemned the reproductive cloning of humans as "unsafe and inefficient." Human reproductive cloning already is banned in South Korea. Other nations, including the United States, are split over whether to ban just human cloning or cloning of all kinds, including the production of stem cells.

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Image
Hwang Woo-Suk, Associated Press

Snuppy, the first cloned dog, right, sits beside the Afghan hound whose cells were used to clone him.

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